Differential vitamin D 24-hydroxylase/CYP24A1gene promoter methylation in endothelium from benign and malignant human prostate
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چکیده
منابع مشابه
Methylation Status of Vitamin D Receptor Gene Promoter in Benign and Malignant Adrenal Tumors
We previously showed a decreased expression of vitamin D receptor (VDR) mRNA/protein in a small group of adrenocortical carcinoma (ACC) tissues, suggesting the loss of a protective role of VDR against malignant cell growth in this cancer type. Downregulation of VDR gene expression may result from epigenetics events, that is, methylation of cytosine nucleotide of CpG islands in VDR gene promoter...
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Forty years ago, Judah Folkman (Folkman. N Engl J Med 285: 1182-1186, 1971) proposed that tumor growth might be controlled by limiting formation of new blood vessels (angiogenesis) needed to supply a growing tumor with oxygen and nutrients. To this end, numerous "antiangiogenic" agents have been developed and tested for therapeutic efficacy in cancer patients, including prostate cancer (CaP) pa...
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27 Forty years ago, Judah Folkman and his colleagues proposed that tumor growth might 28 be controlled by limiting formation of new blood vessels (angiogenesis) needed to supply a 29 growing tumor with oxygen and nutrients. To this end, numerous “anti-angiogenic” agents have 30 been developed and tested for therapeutic efficacy in cancer patients, including prostate cancer 31 (CaP) patients, wi...
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Background & Objective: Malignant breast tumors, which are one of the most important deadly cancers in women, like many other cancers, are proposed to be related to viruses etiologically. Proper management of breast carcinoma necessitates an identification of the etiological factors. Human Papillomavirus is considered to have an etiological role in breast carcinoma. We...
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There are emerging data on novel tumor markers such as matrix metalloproteinase-2 (MMP-2 or gelatinase-A), which play a key role in tissue invasion and metastasis. We designed an investigation to assess the usefulness of MMP-2 activity as compared to prostate specific antigen (PSA) in cancer staging process. We have analyzed the circulating form of MMP-2 in serum samples of patients suffering f...
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ژورنال
عنوان ژورنال: Epigenetics
سال: 2011
ISSN: 1559-2294,1559-2308
DOI: 10.4161/epi.6.8.16536